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Related Experiment Video

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A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo

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Published on: August 11, 2018

Two-step tuberculin skin testing in drug users.

Shobha Swaminathan¹, Ellie E Schoenbaum, Robert S Klein

¹Department of Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07101, USA. swaminsh@umdnj.edu

Journal of Addictive Diseases

|June 28, 2007

Summary

Booster testing for tuberculosis infection in drug users can identify more cases. Factors like older age and crack cocaine use are linked to positive booster tests, improving tuberculosis screening.

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Area of Science:

Infectious Diseases
Public Health
Epidemiology

Background:

Tuberculosis (TB) remains a significant global health concern, particularly in vulnerable populations.
Drug users in methadone treatment programs represent a high-risk group for TB infection.
Two-step tuberculin skin testing is a method to assess latent TB infection.

Purpose of the Study:

To evaluate the effectiveness of booster testing in identifying latent tuberculosis infection (LTBI) among drug users.
To determine demographic and behavioral factors associated with a positive booster test result.

Main Methods:

A cohort of 619 drug users in methadone treatment underwent two-step tuberculin skin testing.
Participants completed interviews on demographics, crack cocaine use, and employment history.
HIV status and CD4+ lymphocyte counts were also assessed.

Main Results:

The initial tuberculin skin test (PPD) was positive in 28% of participants.
Booster testing identified an additional 5% of participants with LTBI.
Positive booster tests were significantly associated with older age, crack cocaine use, and prior work as a home health aide.

Conclusions:

Two-step tuberculin skin testing increased the detection rate of LTBI from 22% to 25% in this population.
Booster testing is a valuable tool for enhancing TB screening among drug users.
Implementing booster testing in TB screening protocols for drug users is recommended due to the efficacy of chemoprophylaxis.