Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Multispecific monoclonal antibodies].

E I Drobyshevskaia, S V Spitsyn, Iu A Nedialkov

    Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
    |September 1, 1991
    PubMed
    Summary

    Immunization can trigger the production of multispecific autoantibodies, potentially causing "immunological noise." This finding is crucial for understanding vaccine development and autoimmune risks.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effect of Immunization with Type 5 Group A Streptococcal Antigens and Liposaccharide (LPS) In Vivo and In Vitro on Splenic and Bone Marrow Multipotent Stromal Cells in Mice.

    Bulletin of experimental biology and medicine·2025
    Same author

    Effect of Activated Immunocompetent Cells on the Content of Multipotent Stromal Cells in Splenic Transplants of CBA and CBA/N Mice Administered with Polyvinylpyrrolidone.

    Bulletin of experimental biology and medicine·2023
    Same author

    MORPHOLOGICAL ANALYSIS OF HEPATITIS B VIRUS WITH ESCAPE MUTATIONS IN S-gene G145R AND S143L.

    Voprosy virusologii·2022
    Same author

    Simultaneous Administration of NOD-2 (MDP) and TLP-4 (LPS) Ligands to Bone Marrow Donors 24 h before Transplantation Increases the Content of Multipotent Stromal Cells (MSCs) in Bone Marrow Grafts in CBA Mice Compared to the Total Result of Their Isolated Administration.

    Bulletin of experimental biology and medicine·2021
    Same author

    Combined Administration of TLR4 (LPS) and TLR3 (Poly I:C) Ligands to CBA Mice Elevates the Content of Osteogenic MSC by 1.6 Times and Increases Content of Bone Marrow MSC to Intermediate Level between Values Attained by Their Individual Administration.

    Bulletin of experimental biology and medicine·2020
    Same author

    Involvement of Bone Marrow Multipotent Stromal Cells in the Processes Presumably Provoking Vascular Calcification.

    Bulletin of experimental biology and medicine·2020

    Area of Science:

    • Immunology
    • Microbiology
    • Autoimmunity

    Context:

    • Bacterial antigens, such as those from Rickettsia prowazekii, Bordetella pertussis, and Legionella pneumophila, are used in vaccines.
    • Immunization responses can be complex, involving both specific and non-specific antibody production.

    Purpose:

    • To investigate the nature of autoantibody synthesis following immunization with bacterial antigens.
    • To explore the concept of antigen-nonspecific 'immunological noise' and its characteristics.

    Summary:

    • Immunization of mice with bacterial antigens induced IgM autoantibodies with broad reactivity, including multispecific antibodies (30-80%).
    • These monoclonal antibodies recognized various bacterial antigens and self-tissue components.
    • A hypothesis suggests that antigen injection normally produces 'immunological noise' comprising autoantibodies.

    Impact:

    • Understanding autoantibody generation is vital for vaccine safety and preventing autoimmune disturbances.
    • Hybridoma techniques can quantify antigen-nonspecific 'immunological noise'.
    • This research has implications for the development of safer and more effective bacterial vaccines.

    Related Experiment Videos