Medical assessment of adverse health outcomes in long-term survivors of childhood cancer
- 1Late Effects Study Group and Outpatient Clinic/Polikliniek Late Effecten Kindertumoren (PLEK), Emma Children's Hospital/Academic Medical Center, Amsterdam, The Netherlands.
- 0Late Effects Study Group and Outpatient Clinic/Polikliniek Late Effecten Kindertumoren (PLEK), Emma Children's Hospital/Academic Medical Center, Amsterdam, The Netherlands.
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View abstract on PubMed
Summary
This summary is machine-generated.Childhood cancer survivors face significant long-term health issues, with many experiencing multiple adverse events by young adulthood, especially after radiotherapy. Lifelong medical surveillance is crucial for managing this burden of disease.
Area Of Science
- Pediatric Oncology
- Cancer Survivorship Research
- Long-Term Health Outcomes
Background
- Childhood cancer survival rates have improved, but survivors often experience multiple treatment-related complications.
- Previous studies primarily focused on single late effects in childhood cancer survivors.
- A comprehensive assessment of the total burden of adverse health outcomes is needed.
Purpose Of The Study
- To evaluate the overall burden of clinical and subclinical adverse events in a large cohort of childhood cancer survivors.
- To analyze long-term medical follow-up data for a comprehensive understanding of late effects.
- To identify the prevalence and severity of adverse events in young adult survivors.
Main Methods
- Retrospective cohort study of 1362 five-year childhood cancer survivors.
- Medical assessments conducted at a dedicated late-effects clinic.
- Standardized grading of adverse events for severity up to January 2004.
Main Results
- High or severe burden of adverse events observed in 55% of radiotherapy survivors and 15% of chemotherapy survivors.
- Bone tumor survivors had the highest incidence (64%) of severe adverse events.
- Nearly 75% of survivors reported at least one adverse event, with 24.6% reporting five or more.
Conclusions
- A significant proportion of childhood cancer survivors experience a high or severe burden of disease in young adulthood.
- Radiotherapy is strongly associated with an increased risk of severe adverse events.
- Risk-stratified, lifelong medical surveillance is essential for managing the long-term health of childhood cancer survivors.
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