Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Osteoclasts in bone metabolism].

Y Hakeda1, M Kumegawa

  • 1Department of Oral Anatomy, Meikai University School of Dentistry, Saitama, Japan.

Kaibogaku Zasshi. Journal of Anatomy
|August 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Estrogen directly down-regulates the bone-resorbing activity of mature osteoclasts through nuclear estrogen receptor alpha.

Cytotechnology·2008
Same author

Dexamethasone inhibits bone resorption by indirectly inducing apoptosis of the bone-resorbing osteoclasts via the action of osteoblastic cells.

Cytotechnology·2008
Same author

Tissue specific expression and differential regulation by 1alpha,25-dihydroxyvitamin D3 of the calcium-sensing receptor (CaSR) gene in rat kidney, intestine, and calvaria.

Cytotechnology·2008
Same author

Tissue inhibitor of metalloproteinases 1 and 2 directly stimulate the bone-resorbing activity of isolated mature osteoclasts.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2002
Same author

High-resolution electron microscopy of the crystallites of fossil enamels obtained from various geological ages.

Journal of dental research·2001
Same author

Milk basic protein promotes bone formation and suppresses bone resorption in healthy adult men.

Bioscience, biotechnology, and biochemistry·2001
Same journal

Results of Questionnaire Survey on Gross Anatomy Education (March 2014).

Kaibogaku zasshi. Journal of anatomy·2018
Same journal

[Biography and My Hope].

Kaibogaku zasshi. Journal of anatomy·2015
Same journal

[Neuroanatomy Bridges to Clinical Fields].

Kaibogaku zasshi. Journal of anatomy·2015
Same journal

[My Profile and Future Approach].

Kaibogaku zasshi. Journal of anatomy·2015
Same journal

[Memoirs of the Late Prof Hisao Fujita].

Kaibogaku zasshi. Journal of anatomy·2015
Same journal

[Cell type-specific inputs to dendritic and somatic compartments of parvalbumin-expressing interneuron in mouse neocortex].

Kaibogaku zasshi. Journal of anatomy·2014
See all related articles

Osteoclasts, crucial for bone remodeling, resorb bone by secreting protons and enzymes. Their differentiation from hematopoietic stem cells is regulated by cytokines and hormones, though pathways require further elucidation.

Area of Science:

  • Cell Biology
  • Biochemistry
  • Skeletal Biology

Context:

  • Osteoclasts are multinucleated giant cells essential for bone modeling and remodeling.
  • They are specialized cells located on bone surfaces, actively involved in bone resorption.
  • Understanding osteoclast function is key to addressing bone-related diseases.

Purpose:

  • To detail the cellular mechanisms of bone resorption by osteoclasts.
  • To explore the differentiation pathways and regulation of osteoclasts.
  • To highlight the role of specific enzymes and ion transport systems in osteoclast activity.

Summary:

  • Osteoclasts resorb bone by creating an acidic microenvironment using proton pumps and degrading organic matrices with lysosomal enzymes.
  • These cells exhibit specialized structures, including a ruffled border for active resorption and a clear zone for attachment.

Related Experiment Videos

  • Osteoclast differentiation originates from hematopoietic stem cells, influenced by cytokines and hormones, with multiple proposed developmental pathways.

    • Impact:

    • Provides a comprehensive overview of osteoclast biology and function.
    • Identifies key molecular players in bone resorption, relevant for therapeutic targets.
    • Clarifies the complex differentiation process of osteoclasts, guiding future research in skeletal biology.