Related Experiment Video
Updated: Jul 14, 2026

Assessing Murine Resistance Artery Function Using Pressure Myography
Published on: June 7, 2013
[Etiology and blood pressure patterns in secondary hypertension in children]
Cristina Gavrilovici1, L V Boiculese, O Brumariu
1Clinica a IV-a Pediatrie, Facultatea de Medicină, Universitatea de Medicină si Farmacie "Gr. T. Popa", Iaşi.
Insights
In children, secondary hypertension is much more common than essential hypertension, with kidney disease being the leading cause. Higher blood pressure in children increases the likelihood of an underlying condition.
Area of Science:
- Pediatrics
- Cardiology
- Nephrology
Context:
- Pediatric hypertension often presents as secondary to underlying conditions, unlike in adults.
- Identifying the etiology of hypertension in children is crucial for effective management and treatment.
- Previous studies indicate a higher prevalence of secondary hypertension in pediatric populations.
Purpose:
- To investigate the causes and patterns of hypertension in a cohort of 256 children over a five-year period.
- To determine the relative frequencies of secondary versus essential hypertension in pediatric patients.
- To explore the relationship between hypertension severity, age, gender, and underlying etiology.
Summary:
- Secondary hypertension was four times more frequent than essential hypertension in the studied pediatric group.
- Renal parenchymal disease (83.2%) and cardiovascular disease (11.4%, primarily coarctation of the aorta) were the most common causes of secondary hypertension.
- Hypertension severity was significantly correlated with the presence of secondary causes, with higher blood pressure indicating a greater chance of an underlying disease.
Impact:
- This study highlights the predominant role of secondary causes in pediatric hypertension, emphasizing the need for thorough etiological investigation.
- Findings underscore the importance of early detection and management of conditions like renal and cardiovascular diseases contributing to childhood hypertension.
- Results provide valuable data for clinicians managing pediatric hypertension, aiding in diagnosis and treatment strategies.
Unlabelled:
Most studies regarding the etiology of hypertension in children have found a frequency of secondary hypertension 4 to 9 times greater the than in adults (70-90% vs. 10%), with a probability of identifying an underlying disease inversely related with the age and directly related with the severity of hypertension.
Material And Method:
The purpose of this study is to establish the causes and the patterns of hypertension in a group of 256 children, admitted during a five-year period in the Children's Hospital "Sf. Maria" Iaşi, Romania.
Results:
The frequency of secondary hypertension is 4 times greater than essential hypertension. The most frequent causes of secondary hypertension are renal parenchymal disease (83.2%) and cardiovascular disease (coarctation of the aorta) (11.4%); less frequent have been diagnosed neurologic (1%) and endocrinologic diseases (1.5%). Most of the assessed cases (referred to our hospital for different other reasons) have been found with stage 1 and 2 of hypertension right from the moment of admission (88.3%). We established a statistically significant relationship between the severity of hypertension and the secondary type of hypertension, meaning : the higher the blood pressure (BP)--the higher chances of diagnosing an underlying cause of hypertension. Among the secondary causes, the renal or non-renal etiology did not significantly influence the BP values at the moment of admission. Among the different histological types of chronic glomerulonephritis, focal segmental glomerulosclerosis presented with a significant higher BP comparing with the other types.
Conclusion:
the frequency of hypertension increased with age: 92.6% of essential hypertension cases belong to age 11-18, 59.2% of renal hypertension cases belong to age 11-18. The exception came from cardiovascular hypertension, which fit into age group 0-6 year old (p < 0.05%). The gender had no significant influence of the etiology of hypertension.
Related Concept Videos
Hypertension I: Introduction
Hypertension and Regulation of Blood Pressure
Hypertension II: Pathophysiology
Hypertension III: Clinical Manifestations and Diagnostic Studies
Alterations in Blood Pressure
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart beats)...
Factors affecting Blood pressure
Physiological Factors: