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Cefpirome susceptibility in staphylococci isolates

Antonia Poiată1, Cristina Tuchiluş, Ioana Bădicuţ

  • 1Disciplina de Microbiologie, Facultatea de Farmacie, Universitatea de Medicină Si Farmacie "Gr. T. Popa", Iaşi.

Revista Medico-Chirurgicala a Societatii De Medici Si Naturalisti Din Iasi
|June 29, 2007
PubMed
Abstract

Insights

Cefpirome demonstrates strong in vitro activity against staphylococci, showing higher susceptibility rates than oxacillin. This fourth-generation cephalosporin is effective against both coagulase-positive and coagulase-negative staphylococci clinical isolates.

Area of Science:

  • Microbiology
  • Infectious Diseases

Background:

  • Cefpirome is a fourth-generation cephalosporin antibiotic.
  • It possesses a broad spectrum of activity against Gram-negative and Gram-positive bacteria.
  • Staphylococci are significant human pathogens, necessitating effective antimicrobial agents.

Purpose of the Study:

  • To evaluate the in vitro antimicrobial activity of cefpirome against clinical isolates of staphylococci.
  • To compare the efficacy of cefpirome with oxacillin, a common antistaphylococcal antibiotic.

Main Methods:

  • A total of 434 staphylococcal isolates were tested: 268 coagulase-positive and 166 coagulase-negative.
  • Susceptibility testing was performed using the Mueller-Hinton agar dilution method.
  • Oxacillin was included as a comparator agent.

Main Results:

  • Cefpirome inhibited most staphylococcal strains at concentrations of 0.5-8 mg/l.
  • High susceptibility rates were observed for cefpirome: 91.6% against coagulase-negative staphylococci and 81.3% against coagulase-positive staphylococci.
  • Oxacillin resistance was observed in 35.1% of coagulase-positive and 26.5% of coagulase-negative staphylococci. Cross-resistance between cefpirome and oxacillin was noted.

Conclusions:

  • Cefpirome exhibited superior in vitro activity against staphylococci compared to oxacillin.
  • The findings support cefpirome's potential as a treatment option for staphylococcal infections.

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