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Effects of Salvia officinalis L. extract on experimental acute inflammation
Ilioara Oniga1, Alina Elena Pârvu, Anca Toiu
1Department of Pharmacognosy, School of Pharmacy, "I. Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca.
Unlabelled:
The aim of this study was to investigate the effects of Salvia officinalis L. tincture on acute inflammation induced with oil of turpentine.
Materials And Methods:
Oil of turpentine (i.m. 0.6 ml/100 g b.w.) was injected into male Wistar rats right hind paw. Salviae folium tincture and diclofenac as positive control (30 mg/100 g b.w.) were administrated i.p. The effects were evaluated by measuring total leukocyte count and differential leukocyte count expressed as a percentage, a test of in vitro phagocytosis and evaluation of nitric oxide synthesis by measuring the metabolites: nitrites and nitrates.
Results:
Salvia officinalis tincture significantly reduced the total leukocyte and monocytes percentages and the activation of circulating phagocytes. NO synthesis had a slight decrease. Salvia officinalis tincture had a smaller inhibitory effect than diclofenac.
Conclusions:
Salvia officinalis tincture had antiinflammatory effects by reducing marrow acute phase response and NO synthesis.
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