Related Experiment Video
Updated: Jul 14, 2026

Exploring Arterial Smooth Muscle Kv7 Potassium Channel Function using Patch Clamp Electrophysiology and Pressure Myography
Published on: September 14, 2012
[Modern conception of protein kinase C role in the vascular smooth muscles tone regulation]
Abstract:
Protein kinase C is an important regulatory enzyme that plays significant role in the vascular tone regulation. Protein kinase C is involved in the vascular smooth muscle cells (SMC) contractility at physiological conditions and its hyperreactivity at different types of pathology. Myogenic and endothelium-dependent pathways of protein kinase C-mediated vascular tone regulation include a variety of cellular mechanisms. The most important protein kinase C-mediated mechanisms in SMC are the increase of myophilament Ca2+-sensitivity; regulation of plasmolema ion permeability, and proliferative changes in SMC. Protein kinase C-related mechanisms in vascular endotheliocytes include regulation of formation and transduction of humoral and electrical signals to SMC that play an important role in the pathological vasospasm development.
More Related Videos
Related Concept Videos
Smooth Muscle Contraction
The onset of contraction is triggered by an increase in calcium ions within the sarcoplasm, similar to the process in striated muscle. However, smooth muscles have a relatively smaller reservoir of the sarcoplasmic...
Nitric Oxide Signaling Pathway
cAMP-dependent Protein Kinase Pathways
Autoregulation of Blood Flow
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation.
Antihypertensive Drugs: Action of Calcium Channel Blockers
Antihypertensive Drugs: Vasodilators

