Collagenous colitis in a patient with systemic sclerosis: a rare entity

Area of Science:

• Gastroenterology
• Rheumatology
• Autoimmune Diseases

Background:

• Collagenous colitis (CC) is a subtype of microscopic colitis characterized by a thickened subepithelial collagen layer.
• CC has been linked to various autoimmune conditions, suggesting a shared underlying pathophysiology.
• The co-occurrence of systemic sclerosis (SSc) and CC is exceptionally rare in clinical practice.

Observation:

• A 65-year-old woman diagnosed with systemic sclerosis presented with persistent diarrhea and abdominal cramping.
• Initial investigations for her gastrointestinal symptoms were inconclusive.
• Colonoscopic examination revealed characteristic findings consistent with collagenous colitis.

Findings:

• Histopathological analysis confirmed collagenous colitis in the patient with systemic sclerosis.
• This case underscores the importance of considering CC in patients with SSc experiencing unexplained gastrointestinal disturbances.
• Review of existing literature reveals limited data on the combined presentation of SSc and CC.

Implications:

• This rare association highlights the complex interplay between systemic autoimmune diseases and gastrointestinal manifestations.
• Recognizing this co-occurrence can aid in earlier diagnosis and appropriate management of patients with systemic sclerosis.
• Further research is warranted to elucidate the specific mechanisms linking systemic sclerosis and collagenous colitis.