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Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
Published on: August 17, 2022
Living donor liver transplantation for biliary atresia
Shih-Ho Wang1, Chao-Long Chen, Allan Concejero
1Liver Transplantation Program, Department of Surgery, Chang Gung Memorial Hospital. 123, Dapi Rd., Niaosong Township, Kaohsiung County 833, Taiwan, ROC.
Insights
Biliary atresia, a liver disease in infants, is treated with Kasai surgery or liver transplants. Living donor liver transplants offer improved survival rates for children with biliary atresia.
Area of Science:
- Pediatric surgery
- Hepatology
- Organ transplantation
Background:
- Biliary atresia is the primary cause of pediatric chronic cholestasis.
- Kasai hepatoportoenterostomy improves survival but may require subsequent liver transplantation.
- Living donor liver transplantation (LDLT) addresses deceased donor organ shortages.
Purpose of the Study:
- To evaluate the outcomes of living donor liver transplantation for biliary atresia.
- To assess the long-term survival rates following LDLT in pediatric patients.
Main Methods:
- Retrospective analysis of 100 living donor liver transplantations for biliary atresia.
- Data collection on recipient survival rates at 1 and 5 years post-transplant.
Main Results:
- A total of 100 LDLTs were performed for biliary atresia.
- Achieved 98% 1-year recipient survival.
- Achieved 98% 5-year recipient survival.
Conclusions:
- Living donor liver transplantation is a highly effective treatment for biliary atresia.
- LDLT significantly improves long-term survival in pediatric patients.
- This approach alleviates organ donor waiting times and enhances patient outcomes.
Abstract:
Biliary atresia is the most common cause of chronic cholestasis in infants and children. The incidence is estimated at 3.7:10,000 among Taiwanese infants. Kasai hepatoportoenterostomy helps children survive beyond infancy. Liver transplantation is indicated when the Kasai procedure fails to work or when patients develop progressive deterioration of liver function despite an initially successful Kasai operation. Living donor liver transplantation was developed to alleviate organ shortage from deceased donors. It has decreased the waiting time for transplantation and, therefore, improves patient survival. One hundred living donor liver transplantations have been performed for biliary atresia at Chang Gung Memorial Hospital-Kaohsiung Medical Center with both 98% 1-year and 5-year actual recipient survival.
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