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Related Concept Videos

Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Antigen Presenting Cells01:22

Antigen Presenting Cells

The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...

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Updated: Jul 14, 2026

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
09:51

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Published on: May 18, 2018

Dendritic cells: key to fetal tolerance?

Sandra M Blois1, Ulrike Kammerer, Catalina Alba Soto

  • 1University Medicine of Berlin, Charité Centrum 12, Internal Medicine and Dermatology, Campus Virchow, 13353 Berlin, Germany. sandra.blois@charite.de

Biology of Reproduction
|June 29, 2007
PubMed
Summary

Successful pregnancy relies on the maternal immune system tolerating the fetus. Uterine dendritic cells (DC) in the decidua are key players in this process, regulating immune responses to prevent rejection.

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Generation of Immature, Mature and Tolerogenic Dendritic Cells with Differing Metabolic Phenotypes
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Last Updated: Jul 14, 2026

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
09:51

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Published on: May 18, 2018

A Simple and Efficient Method for Testing Immunomodulatory Agents for Generation of Tolerogenic Dendritic Cells from Human CD14+ Monocytes
11:34

A Simple and Efficient Method for Testing Immunomodulatory Agents for Generation of Tolerogenic Dendritic Cells from Human CD14+ Monocytes

Published on: April 11, 2025

Generation of Immature, Mature and Tolerogenic Dendritic Cells with Differing Metabolic Phenotypes
06:09

Generation of Immature, Mature and Tolerogenic Dendritic Cells with Differing Metabolic Phenotypes

Published on: June 22, 2016

Area of Science:

  • Immunology
  • Reproductive Biology
  • Cell Biology

Background:

  • Pregnancy involves a fetus, genetically distinct from the mother, developing within the uterus.
  • The maternal immune system must avoid rejecting the fetus (a hemi-allograft) for successful gestation.
  • The decidua, a specialized uterine lining, facilitates fetal tolerance through direct immune cell interactions.

Purpose of the Study:

  • To review and discuss the immunobiology of uterine dendritic cells (DC) in mammalian pregnancy.
  • To explore the role of DC subsets in regulating maternal immune responses towards the fetus.
  • To understand how DC contribute to immune tolerance during fetal-maternal interactions.

Main Methods:

  • Review of current scientific literature on dendritic cell immunobiology.
  • Analysis of research on immune cell interactions at the maternal-fetal interface (decidua).
  • Discussion of identified dendritic cell subsets and their functions in immune regulation.

Main Results:

  • Uterine dendritic cells (DC) are implicated in maintaining pregnancy.
  • DC act as antigen-presenting cells, influencing primary immune responses.
  • Specific DC subsets differentially regulate lymphocyte function and T cell-mediated immunity.

Conclusions:

  • Dendritic cells play a critical role in establishing and maintaining immune tolerance during pregnancy.
  • Understanding DC immunobiology is essential for comprehending fetal-maternal tolerance.
  • Further research into DC subsets can illuminate mechanisms of pregnancy maintenance.