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Updated: Jul 14, 2026

A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis
06:17

A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis

Published on: May 22, 2018

Curcumin derivatives inhibit or modulate beta-amyloid precursor protein metabolism

Rajeshwar Narlawar1, Karlheinz Baumann, Robert Schubenel

  • 1Clemens Schöpf-Institute of Chemistry and Biochemistry, Darmstadt University of Technology, Darmstadt, Germany.

Neuro-Degenerative Diseases
|June 29, 2007
PubMed
Summary

Curcumin analogues, oxazoles and pyrazoles, were synthesized to improve gamma-secretase inhibition by reducing metal chelation. These novel compounds effectively inhibit gamma-secretase, showing potent activity in the low micromolar range.

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