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Updated: Jul 14, 2026
Reconstruct Human Retinoblastoma In Vitro
Published on: October 11, 2022
Clinicopathological parameters and expression of P-glycoprotein and MRP-1 in retinoblastoma
Günhal Kamburoğlu1, Hayyam Kiratli, Figen Söylemezoğlu
1Department of Ophthalmology, Hacettepe University School of Medicine, Ankara, Turkey.
Purpose:
The immunohistochemical expressions of two multidrug resistance proteins, P-glycoprotein (P-gp) and multidrug resistance-related protein-1 (MRP-1), were studied in retinoblastoma and the correlations with the clinicopathological parameters were assessed.
Method:
Sixty-five enucleated eyes containing retinoblastoma were included in the study. Following hematoxylin-eosin staining, tumor differentiation, presence of choroidal invasion, optic nerve invasion, retinal invasion, necrosis and presence of calcification were evaluated with the light microscope. P-gp and MRP-1 expressions were evaluated immunohistochemically.
Results:
Fifty-three eyes were enucleated primarily and 12 eyes were operated after failure of chemotherapy. P-gp and MRP-1 expressions were positive in 69.3 and 73.4% of specimens, respectively. There was no statistically significant relationship between the expressions of P-gp and MRP-1, and tumor differentiation, presence of tumor invasion or treatment with chemotherapy.
Conclusion:
Retinoblastoma intrinsically expresses both P-gp and MRP-1 and their expressions are not related to tumor differentiation. The expressions of P-gp and MRP-1 do not seem to be induced by chemotherapy and are not related to the degree of tumor invasion.
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