Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Exercise and Muscle Performance

Exercise and Muscle Performance

Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...

Exercise and Cardiovascular Response

Exercise and Cardiovascular Response

Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Preclinical efficacy of a gene therapy for <i>CHKB</i>-mediated muscular dystrophy.

Molecular therapy. Advances·2026

Same author

Vamorolone for Duchenne Muscular Dystrophy: A Cross-Trial Efficacy Comparison With Classic Corticosteroids From the FOR-DMD Trial.

Neurology·2026

Same author

Vamorolone Safety, Pharmacokinetics, and Exploratory Efficacy in Duchenne Muscular Dystrophy: A Phase II, Nonrandomized, Multiple-Dose Study in 2-<4-Year-Old Boys.

Neurology·2026

Same author

Results of a phase II open-label, multiple-dose study of vamorolone (VBP15-006) in 7- to < 18-year-old boys with duchenne muscular dystrophy.

Journal of neurology·2026

Same author

Exposure-response of serum biomarkers to vamorolone, a dissociative corticosteroidal anti-inflammatory drug, in 4- to <7-year children.

Steroids·2025

Same author

Circulating protein biomarkers identified in two independent clinical trial cohorts of glucocorticoid-naive Duchenne muscular dystrophy patients.

Scientific reports·2025

Search research articles

Related Experiment Video

Updated: Jul 14, 2026

Dosage-Adjusted Resistance Training in Mice with a Reduced Risk of Muscle Damage

Dosage-Adjusted Resistance Training in Mice with a Reduced Risk of Muscle Damage

Published on: August 31, 2022

Subcutaneous fat alterations resulting from an upper-body resistance training program.

Matthew A Kostek¹, Linda S Pescatello, Richard L Seip

¹Department of Kinesiology, University of Connecticut, Storrs, CT 06269-2101, USA. Matthew.kostek@gmail.com

Medicine and Science in Sports and Exercise

|June 29, 2007

Summary

Resistance training may cause localized fat loss in men, but not women, according to skinfold measurements. However, MRI scans suggest overall fat reduction, not spot reduction, regardless of gender.

More Related Videos

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Published on: January 29, 2016

Related Experiment Videos

Last Updated: Jul 14, 2026

Dosage-Adjusted Resistance Training in Mice with a Reduced Risk of Muscle Damage

Dosage-Adjusted Resistance Training in Mice with a Reduced Risk of Muscle Damage

Published on: August 31, 2022

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Published on: January 29, 2016

Area of Science:

Exercise physiology
Body composition analysis

Background:

The concept of spot reduction, or localized fat loss from exercise, remains debated.
Previous research on spot reduction has yielded inconsistent findings.

Purpose of the Study:

To investigate whether localized subcutaneous fat loss occurs following resistance training.
To compare fat reduction in trained versus untrained limbs.

Main Methods:

104 participants underwent 12 weeks of supervised resistance training on one arm.
Subcutaneous fat was measured using magnetic resonance imaging (MRI) and skinfold calipers before and after training.
Statistical analyses (ANCOVA, linear regression) accounted for gender, age, and BMI.

Main Results:

Skinfold measurements showed a significant decrease in subcutaneous fat in the trained arm of men, but not women.
MRI measurements indicated no significant difference in fat changes between trained and untrained arms for the total sample or by gender.

Conclusions:

Resistance training effects on subcutaneous fat vary by gender and measurement method.
Skinfold data suggest spot reduction in men, while MRI data support generalized fat loss, refuting spot reduction.
MRI's comprehensive measurement revealed variations in response, masking localized effects seen with skinfold calipers.