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Related Experiment Video

Updated: Jul 14, 2026

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
12:09

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

Contrast-enhanced perfusion and diffusion MRI accurately lateralize temporal lobe epilepsy: a pilot study.

T J O'Brien1, E P David, C J Kilpatrick

  • 1Department of Neurology, The Royal Melbourne Hospital, The University of Melbourne, Victoria, Australia. obrientj@unimelb.edu.au

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|June 29, 2007
PubMed
Summary

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Diffusion-weighted imaging (DWI) and contrast-enhanced perfusion imaging (CEPI) show promise for lateralizing non-lesional temporal lobe epilepsy (TLE). These advanced MRI techniques may offer new insights beyond traditional hippocampal volume and T2 relaxometry measures.

Area of Science:

  • Neuroimaging
  • Epilepsy Research
  • Medical Diagnostics

Background:

  • Medically refractory temporal lobe epilepsy (TLE) presents diagnostic challenges, particularly in non-lesional cases.
  • Accurate lateralization is crucial for guiding treatment strategies in TLE.
  • Standard MRI quantitative assessments like volumetric measurements and T2 relaxometry have limitations in non-lesional TLE.

Purpose of the Study:

  • To evaluate magnetic resonance (MR) contrast-enhanced perfusion imaging (CEPI) and diffusion-weighted imaging (DWI) for lateralizing information in medically refractory TLE.
  • To compare the efficacy of CEPI and DWI with standard quantitative hippocampal assessments.
  • To assess the potential of advanced MR techniques in identifying the seizure focus in TLE.

Main Methods:

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A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
08:23

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

Related Experiment Videos

Last Updated: Jul 14, 2026

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
12:09

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
08:23

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

  • A pilot study involving 10 patients with non-lesional TLE and 10 controls.
  • Quantification of relative cerebral blood flow (rCBF) using CEPI and apparent diffusion coefficient (ADC) using DWI in hippocampal regions.
  • Comparison of ipsilateral-to-contralateral side ratios with control group ratios, correlated with EEG lateralization.

    • Main Results:

    • 60% of TLE patients showed abnormal ADC ratios, with larger ADC ipsilateral to EEG lateralization.
    • 100% of patients undergoing CEPI demonstrated abnormal CBF ratios, with lower values ipsilateral to EEG lateralization.
    • No significant correlation was found between hippocampal volume ratios and ADC or CBF ratios, nor a significant relationship with T2 relaxometry ratios.

    Conclusions:

    • DWI and CEPI demonstrate potential as reliable tools for lateralizing non-lesional TLE.
    • These advanced MR techniques may provide complementary information to established quantitative MR measures.
    • Larger studies are needed to confirm the independent diagnostic value of DWI and CEPI in TLE lateralization.