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Related Experiment Video

Updated: Jul 14, 2026

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

Published on: March 14, 2014

Basal cell subpopulation as putative human prostate carcinoma stem cells.

Aleksandar Kuzmanov¹, Soren Hayrabedyan, Milen Karaivanov

¹Institute of Biology and Immunology of Reproduction, Bulgarian Academy of Sciences, Sofia, Bulgaria.

Folia Histochemica Et Cytobiologica

|June 29, 2007

Summary

This study identifies two basal cell types in prostate tissue. Type I basal cells, with high AMACR and low GSTP1, are likely the human prostate carcinoma stem cells.

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Area of Science:

Prostate cancer research
Cell biology
Immunohistochemistry

Background:

Proliferative inflammatory atrophy (PIA) is a precursor lesion in prostate cancer.
Identifying prostate carcinoma stem cells is crucial for understanding cancer development.

Purpose of the Study:

To investigate the expression of p63, GSTP1, and AMACR in PIA.
To identify potential human prostate carcinoma stem cells (PHPCSC) within PIA basal cells.

Main Methods:

Archived prostate tissue sections from 30 radical prostatectomy cases with PIA were analyzed.
Immunohistochemistry was performed using antibodies against AMACR, p63, and GSTP1.
Quantitative immunohistochemistry (QIHC) was used to assess antigen expression levels.

Main Results:

Two distinct populations of p63 basal cells were identified in PIA.
Type I basal cells exhibited high AMACR, low GSTP1, and p63 expression.
Type II basal cells showed low AMACR, high GSTP1, and p63 expression.

Conclusions:

The study proposes that Type I basal cells are the putative human prostate carcinoma stem cells.
This finding contributes to understanding the cellular origins of prostate carcinoma.