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Related Experiment Video

Updated: Jul 14, 2026

Investigating Functional Regeneration in Organotypic Spinal Cord Co-cultures Grown on Multi-electrode Arrays

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Published on: September 23, 2015

Multiple gap phenomena associated with dual His bundle pathways having a lower common tract.

Seiji Takatsuki¹, Fabrice Extramiana, Hideo Mitamura

¹Cardiology Department, Lariboisiere University Hospital, Paris, France. seiji.takatsuki@gmail.com <seiji.takatsuki@gmail.com>

Journal of Electrocardiology

|June 29, 2007

Summary

A single electrical impulse can cause complex heart rhythm changes, including aberrant conduction and unique gap phenomena. This case highlights dual His bundle pathways and retrograde His bundle activation during atrial stimulation.

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Area of Science:

Electrophysiology
Cardiac Electrophysiology
Arrhythmology

Background:

Understanding atrial extrastimulus effects is crucial for diagnosing cardiac arrhythmias.
Aberrant conduction and gap phenomena represent complex electrophysiological events.
Dual pathway physiology in the His bundle can lead to reentrant arrhythmias.

Observation:

A single atrial extrastimulus induced four types of aberrant conduction and two gap phenomena.
One gap phenomenon involved a fast-to-slow jump-up via dual His bundle pathways.
Sharp potentials indicated retrograde His bundle activation, descending the slow and ascending the fast pathway.

Findings:

Demonstration of multiple aberrant conduction patterns from a single extrastimulus.
Characterization of a novel gap phenomenon linked to dual His bundle physiology.
Evidence of retrograde His bundle activation supporting a specific conduction sequence.

Implications:

This case expands the understanding of His bundle electrophysiology and aberrant conduction.
Findings may inform the diagnosis and management of complex supraventricular tachycardias.
Provides insights into the mechanisms underlying specific cardiac rhythm disturbances.