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Minor differences in haplotype frequency estimates can produce very large differences in heterogeneity test

David Curtis1, Ke Xu

  • 1Academic Department of Psychiatry, Queen Mary's School of Medicine and Dentistry, London, UK. david.curtis@qmul.ac.uk

BMC Genetics
|June 29, 2007
PubMed
Summary

Comparing two software programs for genetic association studies revealed that minor variations in estimated haplotype frequencies can lead to substantial differences in statistical significance. This highlights the importance of careful interpretation in genetic research.

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