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Updated: Jul 14, 2026

Analyzing and Building Nucleic Acid Structures with 3DNA
Published on: April 26, 2013
On relationship of Z-curve and Fourier approaches for DNA coding sequence classification
Ngai-Fong Law1, Kin-On Cheng, Wan-Chi Siu
1Centre for Multimedia Signal Processing, Department of Electronic and Information Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong. ennflaw@polyu.edu.hk
Abstract:
Z-curve features are one of the popular features used in exon/intron classification. We showed that although both Z-curve and Fourier approaches are based on detecting 3-periodicity in coding regions, there are significant differences in their spectral formulation. From the spectral formulation of the Z-curve, we obtained three modified sequences that characterize different biological properties. Spectral analysis on the modified sequences showed a much more prominent 3-periodicity peak in coding regions than the Fourier approach. For long sequences, prominent peaks at 2Pi/3 are observed at coding regions, whereas for short sequences, clearly discernible peaks are still visible. Better classification can be obtained using spectral features derived from the modified sequences.
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