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The Multifaceted Benefits of Protein Co-expression in Escherichia coli
Published on: February 5, 2015
Recombinant expression of mouse osteocalcin protein in Escherichia coli
Ji-Hyun Kim1, Soonok Park, Hae-Won Kim
1Department of Biochemistry and BK21 Center for Advanced Medical Education, Inha University College of Medicine, Incheon, 400-712, Korea.
Biotechnology Letters
|June 29, 2007
Abstract:
Osteocalcin is the most abundant non-collagenous protein of bone. Recombinant mouse osteocalcin protein (mOC) that includes the highly conserved central domain for binding to hydroxyapatite (HA), a mineral component of bone, was expressed in Escherichia coli. Purified mOC protein exhibited a significant increase in HA adhesion and differentiation in osteoblast cells as well as binding to HA with high affinity.
