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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
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Related Experiment Video

Updated: Jul 14, 2026

Development of a Human Preclinical Model of Osteoclastogenesis from Peripheral Blood Monocytes Co-cultured with Breast Cancer Cell Lines
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Development of a Human Preclinical Model of Osteoclastogenesis from Peripheral Blood Monocytes Co-cultured with Breast Cancer Cell Lines

Published on: September 13, 2017

Oncogenic osteomalacia.

J J Jacob1, P Finny, Meera Thomas

  • 1Department of Endocrinology, Christian Medical College, Vellore, India.

The Journal of the Association of Physicians of India
|June 30, 2007
PubMed
Summary

A rare phosphaturic mesenchymal tumor caused osteomalacia in a 59-year-old man, leading to severe back pain. Surgical removal of the tumor resulted in complete symptom resolution, highlighting the importance of identifying and excising these rare bone tumors.

Area of Science:

  • Oncology
  • Endocrinology
  • Orthopedics

Background:

  • Osteomalacia, a bone disorder characterized by impaired bone mineralization, can present with significant musculoskeletal pain.
  • Rare mesenchymal tumors can secrete fibroblast growth factor 23 (FGF23), leading to oncogenic osteomalacia.
  • This case highlights a rare cause of secondary osteomalacia.

Observation:

  • A 59-year-old gentleman experienced progressive low back pain and difficulty with squatting for two years.
  • Biochemical tests confirmed osteomalacia.
  • A focal hot spot on blood pool scanning near the left index finger's metacarpophalangeal joint indicated a lesion.

Findings:

  • Biopsy of the excised lesion confirmed a phosphaturic mesenchymal tumor.
  • The tumor was identified as the cause of the patient's oncogenic osteomalacia.

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Last Updated: Jul 14, 2026

Development of a Human Preclinical Model of Osteoclastogenesis from Peripheral Blood Monocytes Co-cultured with Breast Cancer Cell Lines
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Development of a Human Preclinical Model of Osteoclastogenesis from Peripheral Blood Monocytes Co-cultured with Breast Cancer Cell Lines

Published on: September 13, 2017

  • Surgical excision of the tumor was curative.

    • Implications:

    • Early diagnosis and surgical management of phosphaturic mesenchymal tumors are crucial for resolving oncogenic osteomalacia.
    • This case underscores the importance of considering rare tumor types in the differential diagnosis of unexplained osteomalacia.
    • Complete resolution of symptoms following tumor excision demonstrates the efficacy of surgical intervention.