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Updated: Jul 14, 2026

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
Published on: April 1, 2015
[Fibronectin. Structure and functions associated to hemostasis. Review]
Sara Lucena1, Carmen Luisa Arocha Piñango, Belsy Guerrero
1Laboratorio de Fisiopatología, Centro de Medicina Experimental, Instituto Venezolano de Investigaciones Científicas (IVIC), Caracas, Venezuela.
Fibronectin is a key glycoprotein involved in bodily processes. It interacts with various molecules to regulate hemostasis, wound healing, and fibrinolysis.
Area of Science:
- Biochemistry
- Cell Biology
- Molecular Biology
Context:
- Fibronectin is an adhesive glycoprotein found in plasma and extracellular matrix.
- It is widely distributed throughout the body and synthesized by various cells.
- Human plasma fibronectin levels average 300 +/- 100 microg/mL.
Purpose:
- To investigate the multifaceted roles of fibronectin in physiological and pathological processes.
- To elucidate fibronectin's interactions with coagulation and fibrinolysis components.
- To understand fibronectin's regulation of hemostasis and tissue repair.
Summary:
- Fibronectin possesses multifunctional domains enabling interactions with collagen, fibrinogen, fibrin, heparin, factor XIII, and platelets.
- These interactions are crucial for regulating platelet adhesion and aggregation.
- Fibronectin also plays a role in tissue remodeling during wound healing and modulates fibrinolysis via plasminogen activators.
Impact:
- Highlights fibronectin's central role in hemostasis and wound healing.
- Provides insights into the molecular mechanisms underlying fibronectin's functions.
- Establishes fibronectin as a significant factor in diverse biochemical reactions within the body.
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