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Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Glucose Transporters01:27

Glucose Transporters

Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Tuberculosis01:23

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...

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Related Experiment Video

Updated: Jul 14, 2026

Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test
06:59

Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test

Published on: November 13, 2016

Sluggish glucose tolerance in tuberculosis patients.

Luis Bell1, Vishnu Bhat, Grace George

  • 1Department of Medical Biochemistry, Walter Sisulu University, Mthatha, Eastern Cape, South Africa. Lubell@getafix.utr.ac.za

South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
|June 30, 2007
PubMed
Summary

Untreated tuberculosis (TB) patients exhibit significantly altered glucose and insulin metabolism compared to healthy individuals. This metabolic dysregulation may influence the progression of pulmonary tuberculosis.

Related Experiment Videos

Last Updated: Jul 14, 2026

Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test
06:59

Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test

Published on: November 13, 2016

Area of Science:

  • Metabolic Medicine
  • Infectious Diseases
  • Endocrinology

Background:

  • Pulmonary tuberculosis (TB) is a significant global health challenge.
  • Metabolic disturbances are increasingly recognized in infectious diseases.
  • Understanding the metabolic profile of TB patients is crucial for comprehensive patient care.

Purpose of the Study:

  • To investigate glucose tolerance and insulin response in untreated, sputum-positive pulmonary TB patients.
  • To assess potential alterations in glucose and insulin metabolism as part of a broader metabolic profile.
  • To compare metabolic parameters between TB patients and healthy controls.

Main Methods:

  • Sixty-three untreated TB patients and 89 healthy controls participated.
  • Standard oral glucose tolerance tests (OGTTs) were conducted after an overnight fast.
  • Blood glucose and insulin levels were measured at multiple time points post-glucose administration.

Main Results:

  • TB patients demonstrated a significantly sluggish response to glucose and insulin.
  • Elevated glucose and insulin levels were observed in TB patients across all measured time points (0-180 minutes).
  • Statistical analysis revealed highly significant differences (p < 0.0001) in glucose and insulin levels between groups.

Conclusions:

  • The study indicates a distinct alteration in glucose and insulin metabolism in patients with active pulmonary tuberculosis.
  • These metabolic changes may play a critical role in the clinical manifestation and progression of TB.
  • Further research into TB-associated metabolic dysregulation is warranted.