Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Increased generalization between drug-related interoceptive stimuli with delayed testing.

E A MacArdy1, D C Riccio

  • 1Department of Psychology, Kent State University, Ohio 44242.

Behavioral and Neural Biology
|September 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MK-801 induced retrieval, but not acquisition, deficits for passive avoidance conditioning.

Pharmacology, biochemistry, and behavior·2001
Same author

Interpretations of retrograde amnesia: old problems redux.

Nature reviews. Neuroscience·2001
Same author

d-Cycloserine: effects on long-term retention of a conditioned response and on memory for contextual attributes.

Neurobiology of learning and memory·1999
Same author

Ketaset-Rompun extends the temporal gradient for hypothermia-induced retrograde amnesia.

Physiology & behavior·1999
Same author

Post-training glucose administration attenuates forgetting of passive-avoidance conditioning in 18-day-old rats.

Neurobiology of learning and memory·1999
Same author

The contextual change paradox is still unresolved: comment on Bouton, Nelson, and Rosas (1999)

Psychological bulletin·1999

Rats showed state-dependent memory for drug states, with poorer recall when tested in a different state. Generalization between internal drug states flattened over time, similar to external stimuli.

Area of Science:

  • Neuroscience
  • Behavioral Pharmacology
  • Psychopharmacology

Background:

  • Generalization gradients are well-studied with external stimuli.
  • Little research exists on generalization involving internal (interoceptive) stimuli.

Purpose of the Study:

  • Investigate generalization between internal drug states.
  • Examine how memory for internal states changes over time.

Main Methods:

  • Sprague-Dawley rats received chloropent or sodium pentobarbital.
  • Assessed state-dependent retention of a passive avoidance response at 1- and 7-day intervals.

Main Results:

  • Both drugs induced asymmetrical state-dependent retention.
  • Performance was disrupted when switching drug states at 1 day but not at 7 days.

Related Experiment Videos

  • Discriminability between drug states decreased over 7 days.

    • Conclusions:

    • Generalization gradients between drug states flatten over time.
    • Memory for internal stimuli attributes changes similarly to external stimuli.
    • Findings inform contextual cues models of forgetting.