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Effects of desflurane on middle ear pressure
Ozcan Ozturk1, Zekeriya Ilce, Yavuz Demiraran
1Duzce University, Duzce Medical Faculty, Department of Otorhinolaryngology, P. K. 8, 81010 Duzce, Turkey. ozturko_70@yahoo.com
International Journal of Pediatric Otorhinolaryngology
|June 30, 2007
Summary
Desflurane anesthesia significantly increases middle ear pressure in children. This finding suggests desflurane may not be suitable for pediatric middle ear surgeries.
Area of Science:
- Anesthesiology
- Otolaryngology
Background:
- Middle ear pressure (MEP) is crucial for normal hearing function.
- Anesthetic agents can potentially affect MEP, impacting surgical outcomes.
Purpose of the Study:
- To investigate the effect of desflurane on middle ear pressure in pediatric patients.
- To determine if desflurane administration alters MEP during and after anesthesia.
Main Methods:
- A prospective clinical study involving 19 male children undergoing circumcision.
- Tympanometry was used to measure MEP before anesthesia, and at 5, 10, and 15 minutes during desflurane administration, and 10 minutes post-cessation.
- Data were analyzed using the Wilcoxon signed-rank test.
Main Results:
- Desflurane administration led to a significant increase in mean MEP compared to baseline values (p<0.001).
- MEP continued to rise during desflurane administration, peaking at 15 minutes.
- Even after cessation of desflurane, MEP remained significantly elevated compared to pre-anesthesia levels (p<0.001).
Conclusions:
- Desflurane significantly increases middle ear pressure in pediatric patients.
- The observed increase in MEP suggests desflurane may be contraindicated for certain middle ear surgical procedures.
- Further research is warranted to explore the clinical implications of desflurane-induced MEP changes.
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