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Updated: Jul 14, 2026

Failure of Cleaning Verification in Pharmaceutical Industry Due to Uncleanliness of Stainless Steel Surface

Failure of Cleaning Verification in Pharmaceutical Industry Due to Uncleanliness of Stainless Steel Surface

Published on: August 11, 2017

Impact of pharmacy validation in a computerized physician order entry context.

Candice Estellat¹, Isabelle Colombet, Sarah Vautier

¹DEpartement d'Informatique Hospitalière, Hôpital Européen Georges Pompidou, 20-40 rue Leblanc, 75908 Paris cedex 15, France.

International Journal for Quality in Health Care : Journal of the International Society for Quality in Health Care

|June 30, 2007

Summary

Pharmacy validation of computerized physician order entry (CPOE) showed a moderate impact on reducing prescribing errors. CPOE system improvements are needed for pharmacists to focus on critical interventions.

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Last Updated: Jul 14, 2026

Failure of Cleaning Verification in Pharmaceutical Industry Due to Uncleanliness of Stainless Steel Surface

Failure of Cleaning Verification in Pharmaceutical Industry Due to Uncleanliness of Stainless Steel Surface

Published on: August 11, 2017

Area of Science:

Health Informatics
Clinical Pharmacy
Patient Safety

Background:

Computerized physician order entry (CPOE) systems aim to reduce prescribing errors.
Pharmacy validation acts as a secondary error-checking mechanism.
The combined impact of CPOE and pharmacy validation on error reduction has not been previously assessed.

Purpose of the Study:

To evaluate pharmacist interventions during CPOE prescription validation.
To determine the effect of these interventions on the prescribing process.
To assess the contribution of CPOE to identified prescribing errors.

Main Methods:

Prospective study in a tertiary care university hospital over five days.
All medication orders reviewed by pharmacists using CPOE.
Analysis of pharmacy alerts, prescription modifications, and error attribution to CPOE.

Main Results:

11% of order lines (399) triggered pharmacy alerts.
26% of alerts directed to prescribers resulted in prescription modification.
17% of potential prescribing errors were deemed life-threatening; 49% were attributed to CPOE.

Conclusions:

Pharmacy validation offers a moderate short-term reduction in potential prescribing errors.
CPOE system enhancements are crucial for optimizing pharmacist interventions.
Improving CPOE can enable pharmacists to focus on more significant prescribing issues.