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Updated: Jul 14, 2026
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Surgical Tips and Tricks for Performing Porcine Pancreas Transplantation
Published on: July 20, 2022
World's longest surviving liver-pancreas recipient
Albert M Harary1, Kareem Abu-Elmagd, Ngoc Thai
1New York University School of Medicine and Lenox Hill Hospital, New York, NY, USA.
Summary
This study details a groundbreaking liver and pancreas transplant for a patient with type 1 diabetes and hepatitis B. Unique surgical techniques contributed to the patient becoming the longest-surviving combined liver-pancreas recipient.
Area of Science:
- Transplantation immunology
- Hepatology
- Endocrinology
Background:
- Patient presented with type 1 diabetes and end-stage chronic hepatitis B virus infection.
- Combined liver-pancreas transplantation is a complex procedure with variable outcomes.
Observation:
- A cadaveric liver and pancreas were transplanted into the patient in July 1988.
- The surgical approach incorporated two distinct modifications for managing the transplanted organs.
Findings:
- The pancreas utilized enteric drainage for exocrine secretions.
- Pancreatic venous effluent was directed to the host portal system, perfusing the hepatic allograft directly.
Implications:
- These surgical innovations may be key factors in the patient achieving the longest survival duration among liver-pancreas transplant recipients.
- The findings suggest potential improvements in surgical strategies for combined liver-pancreas transplantation.
- Further research into portal delivery of pancreatic effluent could enhance graft survival and function.
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