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Related Experiment Video

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Determination of Biofilm Initiation on Virus-infected Cells by Bacteria and Fungi

Determination of Biofilm Initiation on Virus-infected Cells by Bacteria and Fungi

Published on: July 6, 2016

Bacterial diversity in aphthous ulcers.

L Marchini¹, M S Campos, A M Silva

¹Laboratory of Molecular Genetics and Genomics, University of Vale do Paraíba, São José dos Campos, São Paulo, Brazil.

Oral Microbiology and Immunology

|June 30, 2007

Summary

Bacterial diversity in recurrent aphthous ulcers differs significantly from healthy oral mucosa. Prevotella, a bacterial genus, was exclusively found in ulcer lesions, suggesting a role in this oral condition.

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Area of Science:

Oral microbiology
Molecular diagnostics

Background:

Recurrent aphthous ulcers (RAUs) are common oral mucosal lesions with unknown etiology.
Understanding the microbial composition of RAUs is crucial for identifying potential causes.

Purpose of the Study:

To estimate the bacterial diversity in RAU lesions and control oral mucosa.
To utilize a culture-independent molecular approach for comprehensive analysis.

Main Methods:

DNA extraction from pooled samples of 10 healthy individuals and 10 RAU patients.
16S ribosomal RNA bacterial gene amplification using polymerase chain reaction (PCR).
Sequencing of amplicons and comparison with the GenBank database.

Main Results:

Analysis of 535 clones revealed 95 bacterial species, including 62 novel phylotypes.
RAU lesions harbored 57 phylotypes (11 known species), while controls had 38 (5 known species).
The bacterial genus Prevotella was exclusively detected in RAU lesions, comprising 16% of lesion-derived clones.

Conclusions:

Significant divergence in microbiota between RAU lesions and control mucosa was observed.
The identified rich bacterial diversity offers a new avenue for qualitative and quantitative analyses of bacteria associated with RAUs.