Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...

Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules

Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules

Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...

Bioavailability Enhancement: Drug Permeability Enhancement

Bioavailability Enhancement: Drug Permeability Enhancement

After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Biomarkers of Age-Related Frailty and Frailty Related to Diseases: An Exploratory, Cross-Sectional Analysis from the MAPT Study.

The journal of nutrition, health & aging·2022

Same author

Treatment outcomes of proton beam therapy combined with retrograde intra-arterial infusion chemotherapy for locally advanced oral cancer in the elderly.

International journal of oral and maxillofacial surgery·2022

Same author

Cost-effectiveness of primary prophylaxis of febrile neutropenia with pegfilgrastim in docetaxel, cisplatin and 5-fluorouracil therapy for esophageal cancer.

Die Pharmazie·2021

Same author

Framework Implementation of the INSPIRE ICOPE-CARE Program in Collaboration with the World Health Organization (WHO) in the Occitania Region.

The Journal of frailty & aging·2021

Same author

The INSPIRE Bio-Resource Research Platform for Healthy Aging and Geroscience: Focus on the Human Translational Research Cohort (The INSPIRE-T Cohort).

The Journal of frailty & aging·2021

Same author

Age-Related Frailty: A Clinical Model for Geroscience?

The journal of nutrition, health & aging·2020

Search research articles

Related Experiment Video

Updated: Jul 14, 2026

Formation of Dispersible Taohong Siwu Tablets

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

Formulation and evaluation of lactoferrin bioadhesive tablets.

Y Takahashi¹, C Takeda, I Seto

¹Department of Drug Delivery Research, Hoshi University, 2-4-41 Ebara, Tokyo 142-8501, Japan. taka-y@hoshi.ac.jp

International Journal of Pharmaceutics

|June 30, 2007

Summary

Researchers developed novel bioadhesive tablets using bovine lactoferrin (B-LF) for oral inflammation. Pectin-based tablets with xylitol demonstrated optimal bioadhesion, taste, and therapeutic efficacy in reducing oral ulcers.

More Related Videos

Formulation and Characterization of Bioactive Agent Containing Nanodisks

Formulation and Characterization of Bioactive Agent Containing Nanodisks

Published on: March 17, 2023

Fabrication of Dissolvable Microneedle Patches Loaded with α-Lactalbumin Nanomicelles for Transdermal Capsaicin Delivery and Adipose Tissue Reduction

Fabrication of Dissolvable Microneedle Patches Loaded with α-Lactalbumin Nanomicelles for Transdermal Capsaicin Delivery and Adipose Tissue Reduction

Published on: December 30, 2025

Related Experiment Videos

Last Updated: Jul 14, 2026

Formation of Dispersible Taohong Siwu Tablets

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

Formulation and Characterization of Bioactive Agent Containing Nanodisks

Formulation and Characterization of Bioactive Agent Containing Nanodisks

Published on: March 17, 2023

Fabrication of Dissolvable Microneedle Patches Loaded with α-Lactalbumin Nanomicelles for Transdermal Capsaicin Delivery and Adipose Tissue Reduction

Fabrication of Dissolvable Microneedle Patches Loaded with α-Lactalbumin Nanomicelles for Transdermal Capsaicin Delivery and Adipose Tissue Reduction

Published on: December 30, 2025

Area of Science:

Oral medicine
Pharmacology
Biomaterials science

Background:

Chronic oral inflammation requires effective localized treatments.
Bovine lactoferrin (B-LF) possesses antibacterial and immune-regulatory properties beneficial for oral health.
Developing stable and effective drug delivery systems for oral administration is crucial.

Purpose of the Study:

To formulate and characterize bioadhesive tablets of bovine lactoferrin (B-LF) for treating chronic oral inflammation.
To evaluate the impact of different excipients (pectin, tamarind gum, carboxymethylcellulose) and particle size on tablet properties.
To assess the therapeutic efficacy of the optimized B-LF tablets in an animal model of oral ulcers.

Main Methods:

Bioadhesive tablets were prepared using direct compression with B-LF and various gums (pectin, tamarind gum, CMC).
Tablet properties including bioadhesive force, residence time, and taste were evaluated.
Optimized formulations incorporated xylitol and specific sieve sizes (100-mesh).
Therapeutic effects were assessed in rats with induced oral mucosal ulcers.

Main Results:

CMC-containing tablets exhibited poor bioadhesion.
Tamarind gum tablets offered prolonged oral residence but resulted in an unpleasant taste.
Pectin-based tablets demonstrated superior bioadhesive force and acceptable taste.
Formulation optimization with xylitol and 100-mesh sieve ingredients enhanced tablet characteristics.
B-LF tablets effectively reduced oral ulcer size and associated swelling in rats.

Conclusions:

Pectin-based bioadhesive tablets containing bovine lactoferrin (B-LF) are a promising delivery system for oral inflammation.
Optimized formulations improve palatability and therapeutic effectiveness.
These tablets show potential for managing oral mucosal ulcers and reducing inflammation.