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Updated: Jul 14, 2026

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
Published on: November 15, 2013
Oxazolones as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
Lori Sutin1, Sören Andersson, Lars Bergquist
1Biovitrum AB, SE-112 76, Stockholm, Sweden. lori.sutin@biovitrum.com
Abstract:
2,5,5-Trisubstituted oxazolones were identified as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1). The synthesis, structure-activity relationship and metabolic stability of these compounds are presented.
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