Jove
Visualize
Contact Us

Related Experiment Videos

The influence of dexamethasone in the decrease of chemotherapy-induced nausea and vomiting.

T Sarcev1, N Secen, Dj Povazan

  • 1Clinic for Pulmonary Oncology, Department for Invasive Diagnostics, Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica, Medical Faculty, University of Novi Sad, Serbia. tians@eunet.yu

Journal of B.U.ON. : Official Journal of the Balkan Union of Oncology
|June 30, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Variability of radiation dose in low-dose CT lung cancer screening: A real-world multi-centre protocol comparison.

Radiography (London, England : 1995)·2026
Same author

Contemporary review on spontaneous coronary artery dissection: insights into the angiographic finding and differential diagnosis.

Frontiers in cardiovascular medicine·2023
Same author

Decade of lung cancer in Serbia: tobacco abuse and gender differences.

European review for medical and pharmacological sciences·2023
Same author

Impact of COVID-19 outbreak on hospital admissions and outcome of acute coronary syndromes in a single high-volume centre in southeastern Europe.

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·2021
Same author

Improving physical and mental health in frontline mental health care providers: Yoga-based stress management versus cognitive behavioral stress management.

Journal of workplace behavioral health·2020
Same author

Use of Gonadotropin-Releasing Hormone Analogs in Children: Update by an International Consortium.

Hormone research in paediatrics·2019
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Dexamethasone, combined with standard antiemetics like ondansetron and metoclopramide, significantly reduced chemotherapy-induced nausea and vomiting in lung cancer patients. This combination therapy improved patient outcomes during and after treatment cycles.

Area of Science:

  • Oncology
  • Pharmacology
  • Clinical Medicine

Background:

  • Chemotherapy, including cisplatin and etoposide, frequently causes severe nausea and vomiting.
  • Effective antiemetic strategies are crucial for patient tolerance and treatment adherence in lung cancer therapy.

Purpose of the Study:

  • To evaluate the efficacy of dexamethasone in mitigating cisplatin and etoposide-induced nausea and vomiting.
  • To assess the impact of dexamethasone on chemotherapy side effects in lung cancer patients.

Main Methods:

  • A study involving 60 lung cancer patients divided into two groups.
  • Group A received standard antiemetics (ondansetron, metoclopramide); Group B received the same plus dexamethasone.
  • Patients completed questionnaires on adverse effects, including nausea and vomiting, during and after chemotherapy cycles.

Related Experiment Videos

Main Results:

  • A significant reduction in the frequency and severity of nausea and vomiting was observed in the group receiving dexamethasone.
  • The combination of dexamethasone with ondansetron and metoclopramide demonstrated superior antiemetic effects.

Conclusions:

  • Dexamethasone, when added to serotonin (5-HT3) and dopamine receptor antagonists, substantially decreases chemotherapy-induced nausea and vomiting.
  • This combination represents an effective strategy for managing chemotherapy-related gastrointestinal side effects in lung cancer patients.