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Related Experiment Videos

Menopausal transition: a possible risk factor for brain pathologic events.

S M Bonomo1, A E Rigamonti, M Giunta

  • 1Department of Medical Pharmacology, University of Milan, Fondazione IRCCS Ospedale Maggiore Policlinico, Milan, Italy.

Neurobiology of Aging
|July 3, 2007
PubMed
Summary
This summary is machine-generated.

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Menopausal transition in women alters biological factors, increasing neurodegeneration risk. These changes, including estrogen receptor and interleukin-6 gene expression shifts, are linked to Alzheimer

Area of Science:

  • Neuroscience
  • Endocrinology
  • Genetics

Background:

  • Alzheimer's disease (AD) prevalence is higher in postmenopausal women.
  • Menopause involves significant endocrine and biological changes.
  • Investigating sex- and age-related biological shifts is crucial for understanding neurodegenerative disease risk.

Purpose of the Study:

  • To examine how neuroprotective (estrogen, dehydroepiandrosterone, CD36) and pro-neurotoxic (glucocorticoid, interleukin-6) biological parameters change with age and sex.
  • To compare these biological parameters in healthy individuals and Alzheimer's disease patients.

Main Methods:

  • Gene expression of estrogen receptors (ERs), glucocorticoid receptors (HGRs), interleukin-6 (IL-6), and CD36 was analyzed in leukocytes.
  • Plasma levels of estrogens, cortisol, and dehydroepiandrosterone sulfate (DHEAS) were measured.

Related Experiment Videos

  • Peripheral leukocytes were used due to their accessibility and shared regulatory mechanisms with brain cells.

    • Main Results:

    • In healthy men, biological parameters remained stable with age.
    • In women, menopausal transition showed increased ERs and IL-6 gene expression, an elevated HGR alpha:HGR beta ratio, reduced CD36 expression, and a higher cortisol:DHEAS ratio.
    • These changes in women suggest a predisposition to neurodegeneration, while AD patients showed similar parameter expressions to age- and sex-matched controls.

    Conclusions:

    • Menopausal transition creates a biological environment that increases neurodegeneration risk in women.
    • The higher prevalence of AD in women may be partly due to these biological risk factors, potentially triggered by age-dependent factors like beta-amyloid deposition.