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Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol
Published on: March 25, 2020
Corn fiber oil and sitostanol decrease cholesterol absorption independently of intestinal sterol transporters in
Deepak Jain1, Naoyuki Ebine, Xiaoming Jia
1School of Dietetics and Human Nutrition, Macdonald Campus of McGill University, Ste-Anne-de-Bellevue, QC, Canada.
The Journal of Nutritional Biochemistry
|July 3, 2007
Summary
Corn fiber oil (CFO) and sitostanol effectively lower cholesterol by reducing absorption in hamsters. This cholesterol-lowering effect is independent of key intestinal sterol transporters like ABCG5, ABCG8, and NPC1L1.
Area of Science:
- Nutritional Biochemistry
- Lipid Metabolism
- Molecular Endocrinology
Background:
- Hypercholesterolemia poses a significant global health risk.
- Dietary interventions are crucial for managing cholesterol levels.
- Understanding the mechanisms of cholesterol-lowering compounds is essential.
Purpose of the Study:
- To elucidate the cholesterol-lowering mechanisms of corn fiber oil (CFO), ferulate phytostanyl esters (FPEs), sitostanol, and ferulic acid in hamsters.
- To investigate the impact of these compounds on cholesterol absorption, synthesis, and sterol transporter gene expression.
Main Methods:
- Male Golden Syrian hamsters were fed experimental diets for 4 weeks, including control, cholesterol-supplemented, and diets with CFO, FPE, sitostanol, or ferulic acid.
- Plasma lipid profiles (total cholesterol, HDL cholesterol, triglycerides) were analyzed.
- Cholesterol absorption, synthesis, and mRNA expression of NPC1L1, ABCG5, and ABCG8 were assessed.
Main Results:
- Corn fiber oil (CFO) significantly reduced plasma total cholesterol by 29%.
- Ferulate phytostanyl esters (FPEs) and sitostanol decreased cholesterolemia by 15% and 14%, respectively.
- CFO and sitostanol notably reduced cholesterol absorption by 24% without altering intestinal sterol transporter gene expression.
Conclusions:
- Corn fiber oil (CFO) and sitostanol effectively lower cholesterol by reducing absorption in hamsters.
- The cholesterol-lowering mechanisms of CFO and sitostanol are independent of intestinal sterol transporters NPC1L1, ABCG5, and ABCG8.
- These findings highlight novel pathways for cholesterol management through dietary lipids.
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