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Related Experiment Video

Updated: Jul 14, 2026

Application of Dixon's Up-and-Down Design to Estimate the Minimum Alveolar Concentration of Sevoflurane in Rats with Refined Movement Classification

Application of Dixon's Up-and-Down Design to Estimate the Minimum Alveolar Concentration of Sevoflurane in Rats with Refined Movement Classification

Published on: July 25, 2025

Sitting position does not alter minimum alveolar concentration for desflurane.

Chun-Ming Lin¹, Chieh-Tsai Wu, Shih-Tseng Lee

¹Department of Anesthesiology, Chang Gung Memorial Hospital, 5, Fu-Hsing St., Tao Yuan, Taiwan. sam2498@adm.cgmh.org.tw

Canadian Journal of Anaesthesia = Journal Canadien D'Anesthesie

|July 3, 2007

Summary

The sitting position does not alter desflurane anesthetic requirements for immobility during surgery. This finding suggests anesthetic depth does not need adjustment based on patient positioning for this procedure.

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In Vitro Method to Control Concentrations of Halogenated Gases in Cultured Alveolar Epithelial Cells

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Published on: October 23, 2018

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Last Updated: Jul 14, 2026

Application of Dixon's Up-and-Down Design to Estimate the Minimum Alveolar Concentration of Sevoflurane in Rats with Refined Movement Classification

Application of Dixon's Up-and-Down Design to Estimate the Minimum Alveolar Concentration of Sevoflurane in Rats with Refined Movement Classification

Published on: July 25, 2025

In Vitro Method to Control Concentrations of Halogenated Gases in Cultured Alveolar Epithelial Cells

In Vitro Method to Control Concentrations of Halogenated Gases in Cultured Alveolar Epithelial Cells

Published on: October 23, 2018

Area of Science:

Anesthesiology
Surgical Positioning
Pharmacodynamics

Background:

Hypotension is a common anesthesia complication in the sitting position, potentially leading to inadequate anesthesia.
Baroreceptor unloading in the sitting position can increase CNS arousal, while hypotension has a depressant effect.
Understanding anesthetic requirements is crucial for patient safety and optimal surgical conditions.

Purpose of the Study:

To determine the minimal alveolar concentration (MAC) of desflurane for immobility in patients undergoing surgery in the sitting position.
To compare desflurane MAC requirements in the sitting position versus the supine position for similar surgeries.
To investigate the influence of surgical positioning on anesthetic needs.

Main Methods:

The Dixon up-and-down method was used to assess desflurane MAC for immobility in 48 patients (24 sitting, 24 supine).
Logistic regression analyzed the concentration-response relationship for immobility across positions.
Monte Carlo simulation calculated 95% confidence intervals and the difference in MAC (delta MAC).

Main Results:

The simplified model, treating sitting and supine groups as one, did not significantly differ from separate models (P = 0.098).
The overall MAC for desflurane was 6.61% (95% CI: 6.52-6.70).
The mean difference in MAC between sitting and supine positions was -0.14% (95% CI: -0.30-0.03).

Conclusions:

The sitting position does not significantly alter desflurane anesthetic requirements for immobility.
Anesthetic management for immobility may not require position-specific adjustments for desflurane.
These findings contribute to optimizing anesthetic delivery during surgeries performed in the sitting position.