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Testing of Nanoparticle Release from a Composite Containing Nanomaterial Using a Chamber System

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Published on: November 22, 2016

Nanotechnology safety concerns revisited.

Stephan T Stern¹, Scott E McNeil

¹Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA. sternstephan@mail.nih.gov

Toxicological Sciences : an Official Journal of the Society of Toxicology

|July 3, 2007

Summary

Nanomaterial safety research reveals that risks are material-specific, not generalized. Current data suggest limited systemic exposure and low acute toxicity, but pulmonary risks warrant further study.

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Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Published on: December 9, 2010

Area of Science:

Nanotechnology safety and risk assessment.
Environmental health and toxicology of engineered nanomaterials.

Background:

Growing concerns regarding nanomaterial risks have spurred significant safety research.
Existing knowledge gaps hinder comprehensive risk assessment for nanotechnology applications.

Purpose of the Study:

To review and synthesize published findings on nanomaterial safety.
To identify areas of consensus and disagreement regarding exposure, hazard, and risk.
To evaluate study designs and methodologies in nanomaterial safety assessment.

Main Methods:

Comprehensive literature review of published nanomaterial safety studies.
Analysis of study designs, methodologies, and data on exposure and toxicity.
Evaluation of evidence regarding human and environmental health impacts.

Main Results:

Nanomaterial risks are material-specific, not generalized; size-dependent paradigms are inadequate.
Lung, gastrointestinal tract, and skin act as barriers to systemic exposure for many nanomaterials.
Acute systemic toxicity is generally low, but pulmonary toxicity (e.g., carbon nanotubes) can be significant.

Conclusions:

Current nanomaterial safety data are limited, necessitating cautious development.
Further research is required to define exposures, hazards, and environmental life cycles.
Material-specific risk assessment is crucial, emphasizing the need for detailed characterization.