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Updated: Jul 14, 2026

Force-Clamp Rheometry for Characterizing Protein-based Hydrogels
Published on: August 21, 2018
Formation of viscoelastic protein droplets on a chemically functionalized surface
Abstract:
Droplet formation during adsorption of the protein lactoferrin from an aqueous solution on a surface functionalized by plasma deposited poly(acrylic acid) is studied using quartz crystal microbalance and atomic force microscopy. The formation of protein droplets is particularly favored at pH values close to the isoelectric point of lactoferrin, where the molecules carry little excess charge and intermolecular attraction exceeds the molecule-surface interaction. By combining topographic data with information on the system dynamics, it is possible to describe the viscoelastic properties of the adsorbate within a quantitative model for nonhomogeneous layers.
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