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Updated: Jul 14, 2026

Dual-modality Molecular Cartography: Integrating Multiplex mRNA Detection with Protein Imaging Mass Cytometry
Published on: November 14, 2025
Identity profiling of cell surface markers by multiplex gold nanorod probes
Chenxu Yu1, Harikrishna Nakshatri, Joseph Irudayaraj
1Department of Agricultural and Biological Engineering and Bindley Biosciences Center, Purdue University, 225 South University Drive, West Lafayette, Indiana 47906, USA.
Abstract:
Gold nanorod molecular probes (GNrMPs) were designed and fabricated for multiplex identification of cell surface markers in HBECs. Cells were probed directly using dark field microscopy integrated with a spectral imager for simultaneous detection of up to three surface markers. The immunophenotype composition of these cell lines indicative of their metastasis potential was assessed using the GNrMPs. The technique has the potential to become an important tool for diagnosis and prognosis of breast and other cancers.

