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Updated: Jul 14, 2026

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes
Published on: June 13, 2014
Adhesion molecules and cytokine expression in fibromyalgia patients: increased L-selectin on monocytes and
Joana A Macedo1, Judith Hesse, Jonathan D Turner
1Institute of Immunology, Laboratoire National de Santé, Luxembourg.
Abstract:
Several lines of evidence implicate the immune system in the pathophysiology of fibromyalgia (FM). We investigated the role of cytokines and adhesion molecules involved in immune cell trafficking and the influence of 1.5 mg of dexamethasone (DEX) per os on their expression. L-selectin was elevated on monocytes and neutrophils of FM patients. Differences in group response to DEX were observed for CD11b on NK cells, sICAM-1 and IL-2. This study shows a slight disturbance in the innate immune system of FM patients, and suggests an enhanced adhesion and recruitment of leukocytes to inflammatory sites.
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