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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...

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Related Experiment Video

Updated: Jul 14, 2026

Murine Ileocolic Bowel Resection with Primary Anastomosis
08:49

Murine Ileocolic Bowel Resection with Primary Anastomosis

Published on: October 29, 2014

Perianal Crohn's disease.

Scott A Strong1

  • 1Departments of Colorectal Surgery and Pathobiology, Cleveland Clinic, Cleveland, Ohio 44195, USA. strongs@ccf.org

Seminars in Pediatric Surgery
|July 3, 2007
PubMed
Summary

Perianal Crohn's disease in children involves varied anal and skin lesions. Management requires thorough evaluation and combined therapies, including medications and conservative surgery, to improve symptoms while preserving function.

Area of Science:

  • Pediatric Gastroenterology
  • Colorectal Surgery
  • Inflammatory Bowel Disease Research

Background:

  • Perianal Crohn's disease (PCD) in children is a significant complication that can appear before or after intestinal symptoms.
  • PCD manifests in diverse ways, including skin lesions, anal canal abnormalities, abscesses, fistulas, and rare malignancies.
  • Effective management hinges on comprehensive assessment of the perianal region and the entire gastrointestinal tract.

Purpose of the Study:

  • To outline the varied clinical presentations of perianal Crohn's disease in pediatric patients.
  • To detail the diagnostic approach for perianal Crohn's disease in children.
  • To review current therapeutic strategies for managing pediatric perianal Crohn's disease.

Main Methods:

  • Literature review of perianal Crohn's disease in pediatric populations.

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A Rat Model of Pouchitis Following Proctocolectomy and Ileal Pouch-Anal Anastomosis Using Dextran Sulfate Sodium

Published on: May 31, 2024

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Last Updated: Jul 14, 2026

Murine Ileocolic Bowel Resection with Primary Anastomosis
08:49

Murine Ileocolic Bowel Resection with Primary Anastomosis

Published on: October 29, 2014

A Rat Model of Pouchitis Following Proctocolectomy and Ileal Pouch-Anal Anastomosis Using Dextran Sulfate Sodium
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A Rat Model of Pouchitis Following Proctocolectomy and Ileal Pouch-Anal Anastomosis Using Dextran Sulfate Sodium

Published on: May 31, 2024

  • Analysis of diagnostic modalities for perianal abnormalities.
  • Synthesis of treatment guidelines encompassing medical and surgical interventions.

    • Main Results:

    • Perianal lesions in children with Crohn's disease are heterogeneous, impacting skin, anal canal, and potentially leading to abscesses or fistulas.
    • A multidisciplinary approach integrating gastroenterology and surgery is crucial for accurate diagnosis and tailored treatment.
    • Therapeutic options include antibiotics, immunomodulators, biologics, and conservative surgical procedures.

    Conclusions:

    • Perianal Crohn's disease requires prompt and thorough evaluation in pediatric patients.
    • Integrated medical and surgical management aims to alleviate symptoms and maintain anorectal function.
    • Long-term monitoring is essential for managing this chronic condition in children.