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Related Experiment Video

Updated: Jul 14, 2026

Dissection and Lateral Mounting of Zebrafish Embryos: Analysis of Spinal Cord Development
05:36

Dissection and Lateral Mounting of Zebrafish Embryos: Analysis of Spinal Cord Development

Published on: February 28, 2014

Curcumin affects development of zebrafish embryo.

Jheng-Yu Wu1, Chin-Yi Lin, Tien-Wei Lin

  • 1Department of Biology, National Changhua University of Education, Changhua, Taiwan, Republic of China.

Biological & Pharmaceutical Bulletin
|July 3, 2007
PubMed
Summary

Curcumin exposure causes developmental defects in zebrafish embryos, including bent tails and shorter body length. Zebrafish serve as a valuable model for studying curcumin

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Area of Science:

  • Developmental toxicology
  • Zebrafish model organism studies
  • Natural product chemical effects

Background:

  • Curcumin, a natural compound, has various biological activities.
  • Understanding its developmental toxicity is crucial for safety assessments.

Purpose of the Study:

  • To investigate the embryotoxic and teratogenic effects of curcumin on zebrafish embryos.
  • To establish zebrafish as a model for curcumin toxicity studies.

Main Methods:

  • Exposure of zebrafish embryos and larvae to varying concentrations of curcumin.
  • Estimation of LD(50) values for curcumin.
  • Observation and documentation of developmental abnormalities.
  • Fluorescence imaging to track curcumin distribution.

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Related Experiment Videos

Last Updated: Jul 14, 2026

Dissection and Lateral Mounting of Zebrafish Embryos: Analysis of Spinal Cord Development
05:36

Dissection and Lateral Mounting of Zebrafish Embryos: Analysis of Spinal Cord Development

Published on: February 28, 2014

Zebrafish Larvae as a Model to Evaluate Potential Radiosensitizers or Protectors
04:53

Zebrafish Larvae as a Model to Evaluate Potential Radiosensitizers or Protectors

Published on: August 25, 2022

Rapid Evaluation of Toxicity of Chemical Compounds Using Zebrafish Embryos
07:49

Rapid Evaluation of Toxicity of Chemical Compounds Using Zebrafish Embryos

Published on: August 25, 2019

Main Results:

  • Curcumin LD(50) values were 7.5 microM (embryos) and 5 microM (larvae) after 24-h incubation.
  • Observed defects included bent tails, spinal curvature, pericardial edema, yolk sac resorption retardation, and reduced body length.
  • Curcumin fluorescence was detected in edema sacs and skin cells of treated larvae.

Conclusions:

  • Curcumin exhibits significant embryotoxic and teratogenic effects in zebrafish.
  • Zebrafish are a suitable model for investigating the developmental toxicity of curcumin and similar compounds.