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Updated: Jul 14, 2026

A Simple Cell-based Immunofluorescence Assay to Detect Autoantibody Against the N-Methyl-D-Aspartate (NMDA) Receptor in Blood
Published on: January 9, 2018
Paraneoplastic limbic encephalitis caused by ovarian teratoma with autoantibodies to glutamate receptor
Sadahisa Okamoto1, Teruyuki Hirano, Yukitoshi Takahashi
1Department of Neurology, Graduate School of Medical Sciences, Kumamoto University. s-okamoto@fc.kumamoto-u.ac.jp
Abstract:
We report a rare case of paraneoplastic limbic encephalitis with autoantibodies to glutamate receptor (GluR) in the cerebrospinal fluid (CSF). The 35-year-old woman with consciousness disturbance was diagnosed initially as non-herpetic encephalitis. Her signs and symptoms improved with acyclovir and steroid pulse therapy. However, after the treatment, an ovarian tumor was discovered, and we detected autoantibodies to GluR in the CSF. A possible association between the ovarian teratoma and GluR is suggested.
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