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Related Experiment Videos

[Clinical xenotransplantation].

Shuji Miyagawa1

  • 1Division of Organ Transplantation, Department of Molecular therapeutics, Osaka University Graduate School of Medicine.

Nihon Rinsho Men'Eki Gakkai Kaishi = Japanese Journal of Clinical Immunology
|July 3, 2007
PubMed
Summary
This summary is machine-generated.

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Xenotransplantation research is advancing with genetically modified pigs to overcome organ rejection. Clinical trials for pig islet transplantation are expanding, offering hope for patients needing organ replacements.

Area of Science:

  • Xenotransplantation research
  • Immunology
  • Genetics

Context:

  • Growing shortage of human donor organs fuels interest in xenotransplantation.
  • Previous clinical trials of pig islet transplantation conducted globally until 2005.
  • New clinical trials for pig islet transplantation are planned in the USA.

Purpose:

  • Review clinical aspects of xenotransplantation.
  • Discuss the production of genetically modified pigs for xenotransplantation.
  • Summarize strategies to overcome xenogenic rejection and assess porcine endogenous retrovirus (PERV) infectivity.

Summary:

  • Genetically modified pigs expressing human complement regulatory protein (CRP) and lacking alpha-Gal epitopes are being developed.
  • Research focuses on downregulating immune responses against xenografts, including complement activation and NK cell activity.

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  • Studies also address the infectivity of porcine endogenous retrovirus (PERV) to human cells.

    • Impact:

    • Genetically engineered pigs offer potential solutions for organ transplantation.
    • Advancements in xenotransplantation may alleviate organ donor shortages.
    • Understanding and mitigating immune rejection are crucial for successful xenotransplantation outcomes.