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[Toxicologic and pharmacologic study of tributyltin oxide (TBTO)]
Abstract:
Toxicological study on bis-(tributyl-tin) oxyde shows a delayed toxicity of this compound in acute experiments. The same result is obtained in sub-chronic study. Most of the animals die after a great loss of weight. In pharmacological study, T. B. T. O. depresses central nervous system, but his action on ortho and parasympathetic system is slight and non specific. In rat, rabbit and dog, the effect is a fall in blood pressure that result from a depression of the vascular smooth muscle. The death of the animal is due to respiratory arrest by a central mechanism.
Insights
Bis-(tributyl-tin) oxide (TBTO) exhibits delayed toxicity in acute and sub-chronic studies, leading to significant weight loss and death. TBTO also depresses the central nervous system and causes a blood pressure fall via vascular smooth muscle depression.
Area of Science:
- Environmental toxicology
- Pharmacology
- Mammalian toxicology
Context:
- Bis-(tributyl-tin) oxide (TBTO) is an organotin compound with industrial applications.
- Understanding the toxicological profile of TBTO is crucial for risk assessment.
- Limited data exists on the specific mechanisms of TBTO toxicity in mammals.
Purpose:
- To investigate the acute and sub-chronic toxicity of bis-(tributyl-tin) oxide.
- To elucidate the pharmacological effects of TBTO on the central and peripheral nervous systems.
- To determine the mechanism of lethality induced by TBTO exposure.
Summary:
- Toxicological studies revealed a delayed toxicity of TBTO in both acute and sub-chronic experimental models.
- A significant finding was that most animals succumbed following substantial body weight reduction.
- Pharmacological assessments indicated that TBTO depresses the central nervous system.
- The compound exerted slight and non-specific effects on the ortho and parasympathetic systems.
- In rats, rabbits, and dogs, TBTO induced a decrease in blood pressure attributed to vascular smooth muscle depression.
- The ultimate cause of death in the tested animals was respiratory arrest mediated by a central mechanism.
Impact:
- This research highlights the insidious nature of TBTO toxicity, emphasizing the need for careful handling and exposure control.
- Findings provide critical insights into the neurotoxic and cardiovascular effects of organotin compounds.
- The study contributes to a better understanding of the toxicological mechanisms, informing regulatory policies and safety guidelines for TBTO.