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Updated: Jul 14, 2026

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells
Published on: September 12, 2019
Yolk sac tumor of the vagina
Parvin Mahzouni1, Shervin Pejhan, Mahmoud Ashrafi
1Department of Pathology, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
Abstract:
Malignant germ-cell tumors GCT are rare tumors of childhood accounting for less than 3% of pediatric malignancies. Endodermal sinus tumors EST form the most common histologic subtype of malignant GCT. The vagina is an extremely rare site for GCTs. An 8-month-old female was admitted with a short history of vaginal bleeding, and a mass protruding from the vagina. A mass was palpable anteriorly on rectal examination. Computed tomography showed a tumor mass posterior to the bladder. A biopsy revealed a vaginal EST. The serum alpha-fetoprotein was elevated. Vaginohysterectomy was carried out. She was subsequently referred to the oncologist for further management.
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