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Integrated olfactory receptor and microarray gene expression databases.

Nian Liu1, Chiquito J Crasto, Minghong Ma

  • 1Center for Medical Informatics, Yale University School of Medicine, New Haven, CT 06520, USA. nian.liu@yale.edu

BMC Bioinformatics
|July 3, 2007
PubMed
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The Olfactory Receptor Microarray Database (ORMD) houses olfactory receptor gene expression data, aiding olfactory research. Integrated with the Olfactory Receptor Database (ORDB), it links expression data with genomic and functional information for olfactory receptors.

Area of Science:

  • Neuroscience
  • Genomics
  • Bioinformatics

Background:

  • Olfactory receptor (OR) gene expression patterns are crucial for olfactory signal encoding.
  • Understanding these patterns is key to deciphering odorant-ligand interactions with sensory neurons.

Purpose of the Study:

  • To develop a centralized repository for olfactory receptor gene expression data.
  • To integrate gene expression data with existing genomic and functional information.

Main Methods:

  • Developed the Olfactory Receptor Microarray Database (ORMD) as a web-accessible, secure data repository.
  • Integrated ORMD with the Olfactory Receptor Database (ORDB).
  • Enabled data deposition, project management, and access to both public and private datasets.

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Main Results:

  • ORMD provides a platform for managing and depositing OR microarray experiments.
  • Users can access raw data, view, and export gene expression data.
  • Hyperlinks connect ORMD entries to ORDB for comprehensive genomic and proteomic information.

Conclusions:

  • ORMD functions as a vital data repository and project management tool for olfactory research.
  • The integration with ORDB provides a unified resource linking gene expression with OR genomic and functional data.
  • ORMD is a valuable resource for olfactory researchers and the public, facilitating studies on gene expression in the olfactory system.