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Serum prolidase activity in patients with hypertension and its relation with left ventricular hypertrophy

Recep Demirbag1, Ali Yildiz, Mustafa Gur

  • 1Department of Cardiology, Medical Faculty, Harran University, Sanliurfa, Turkiye, P.K: 112, Sanliurfa, Turkey. rdemirbag@yahoo.com

Clinical Biochemistry
|July 3, 2007
PubMed

Insights

Serum prolidase activity is lower in hypertensive patients, correlating with hypertension presence and duration. This enzyme

Area of Science:

  • Biochemistry
  • Cardiology
  • Clinical Medicine

Background:

  • Hypertension is a major cardiovascular risk factor.
  • Left ventricular hypertrophy (LVH) is a common complication of hypertension.
  • The role of serum prolidase activity in hypertension and LVH requires further investigation.

Purpose of the Study:

  • To determine serum prolidase activity in patients with hypertension.
  • To investigate the relationship between serum prolidase activity and left ventricular hypertrophy in hypertensive patients.

Main Methods:

  • Serum prolidase activity was measured spectrophotometrically.
  • Participants were divided into three groups: controls, hypertensive patients with LVH, and hypertensive patients without LVH.
  • Statistical analyses included ANOVA and multivariate analysis.

Main Results:

  • Serum prolidase activity was significantly lower in the control group compared to hypertensive groups.
  • Prolidase activity showed a significant correlation with the presence and duration of hypertension.
  • Prolidase activity was not significantly correlated with left ventricular mass index.

Conclusions:

  • Serum prolidase activity is associated with hypertension.
  • This association is independent of left ventricular hypertrophy.
  • Serum prolidase may serve as a potential biomarker in hypertension management.
Abstract

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