Related Experiment Video
Updated: Jul 14, 2026

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans
Published on: September 7, 2021
E2A proteins: regulators of cell phenotype in normal physiology and disease
Craig Slattery1, Michael P Ryan, Tara McMorrow
1School of Biomedical Sciences, Skerman Building, University of Queensland, St. Lucia, Queensland 4072, Australia. c.slattery@uq.edu.au
Abstract:
The E2A gene encodes two distinct basic helix-loop-helix transcription factors, E12 and E47. E12 and E47 modulate expression of their target genes through formation of homodimers and heterodimers with other basic helix-loop-helix transcription factors. E2A proteins are thought to play critical roles in regulation of cell commitment, growth and differentiation in a range of cell types including lymphocytes, muscle cells and neurons. Emerging evidence suggests that E2A proteins also play key roles in the process of epithelial mesenchymal transition, a mechanism which contributes significantly to kidney disease progression and tumour metastasis. Further understanding of the diverse effects of E2A proteins may lead to novel therapeutic approaches to targeting important disease process.
More Related Videos
11:32Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
Published on: March 27, 2020
12:38Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism
Published on: December 18, 2013
Related Concept Videos
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
Master Transcription Regulators
Negative Regulator Molecules
Regulated Protein Degradation
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
Abnormal Proliferation
Cadherins in Tissue Organization
Cell Sorting During Development
Cell sorting plays an...