Related Experiment Video
Updated: Jul 14, 2026

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
Published on: September 20, 2017
Extended Hansen's solubility approach: meloxicam in individual solvents
P R Sathesh Babu1, C V S Subrahmanyam, J Thimmasetty
1Bapuji Pharmacy College, Davangere, Karnataka, India. satish_puvvadi@rediffmail.com
Abstract:
The solubility behaviour of meloxicam in individual solvents ranging from non-polar to highly polar was studied. For understanding the solute-solvent interactions, partial solubility parameters concept was utilized. The extended Hansen's method was used for analyzing the solubility data and for obtaining partial solubility parameters of meloxicam. The analysis was not successful though correlations were 81%. The Flory-Huggins size correction term 'B' was found to improve the prediction of solubility. The correlations were high (92%) and total solubility parameter was 11.6 H. The four-parameter approach involving proton-donor and proton-acceptor parameters was also used in fitting the solubility data. The correlations were appreciable (87%) and total solubility parameter was 11.2 H. The term 'B' combined with four-parameter approach was also used in order to improve the data, and was found to be improved the correlations (R2=0.94). This new approach may thus be used in fitting the experimental solubility data and to predict solubility behaviour of meloxicam in untested solvents. The total solubility parameter of meloxicam was assigned at 11.2 H.
Related Concept Videos
Solubility
A solution is a homogeneous mixture composed of a solvent, the major component, and a solute, the minor component. The physical state of a solution—solid, liquid, or gas—is typically the same as that of the solvent. Solute concentrations are often described with qualitative terms such as dilute (of relatively low concentration) and concentrated (of relatively high concentration).
In a solution, the solute particles (molecules, atoms, and/or ions)...
Solvents
A...
Comparing Intermolecular Forces: Melting Point, Boiling Point, and Miscibility
Temporary attractive forces like dispersion are present in all molecules, whether they are polar or nonpolar. They...
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
Solubility Equilibria: Overview
Solubility is important in biological and environmental processes. A notable...
Solubility Equilibria
The...

