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Related Experiment Videos

Relations between the fetal circulation and pituitary-thyroid function.

J G Thorpe-Beeston1, K H Nicolaides, R J Snijders

  • 1Department of Obstetrics and Gynaecology, King's College School of Medicine and Dentistry, Denmark Hill, London, UK.

British Journal of Obstetrics and Gynaecology
|November 1, 1991
PubMed
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Fetal thyroid hormone levels correlate with blood flow changes in growth-restricted and isoimmunized fetuses. These circulatory alterations may aid fetal survival in adverse intrauterine conditions.

Area of Science:

  • Perinatology
  • Fetal Medicine
  • Endocrinology

Background:

  • Fetal thyroid hormones play a crucial role in development.
  • Doppler ultrasound is a key tool for assessing fetal circulation.
  • Understanding fetal circulatory responses to hormonal changes is vital for managing high-risk pregnancies.

Purpose of the Study:

  • To investigate the relationship between fetal thyroid hormone and thyroid-stimulating hormone (TSH) levels and fetal circulatory alterations.
  • To assess changes in fetal blood flow using Doppler ultrasound in fetuses with small for gestational age (SGA) and red-cell isoimmunization.

Main Methods:

  • A cross-sectional study involving 38 SGA and 38 red-cell isoimmunized fetuses.
  • Cordocentesis was performed for blood sampling and analysis of thyroid hormones (TSH, T4, FT4, T3, FT3), Po2, and hemoglobin (Hb).

Related Experiment Videos

  • Doppler ultrasound was used to measure mean blood velocities in the middle cerebral artery (MCAVm) and descending thoracic aorta (AoVm).

    • Main Results:

    • Mean AoVm was elevated in isoimmunized fetuses but reduced in SGA fetuses.
    • Mean MCAVm increased in both SGA and isoimmunized groups.
    • Significant associations were found between TSH and MCAVm, and between T4/FT4/FT3 and AoVm. T4 and FT4 also correlated with Po2 and Hb.

    Conclusions:

    • Significant associations exist between fetal thyroid hormone levels and fetal blood flow changes in conditions like growth retardation and rhesus disease.
    • These observed circulatory changes, regardless of causality, might contribute to fetal survival in compromised intrauterine environments.
    • The findings highlight the interplay between fetal endocrine and circulatory systems in high-risk pregnancies.