Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Systemic inflammation and lung function in young adults.

Robert J Hancox1, Richie Poulton, Justina M Greene

  • 1Dunedin Multidisciplinary Health and Development Research Unit, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand. bob.hancox@otago.ac.nz

Thorax
|July 3, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cranial Base Characteristics in Adults with Obstructive Sleep Apnoea and Matched Controls: A Retrospective CBCT Study.

Dento maxillo facial radiology·2026
Same author

Comparison of nasal passage and palatal volume in obstructive sleep apnea patients and healthy individuals using cone beam computed tomography.

Sleep & breathing = Schlaf & Atmung·2025
Same author

Behavioural components and delivery features of early childhood obesity prevention interventions: intervention coding of studies in the TOPCHILD Collaboration systematic review.

The international journal of behavioral nutrition and physical activity·2025
Same author

Medical emergencies in hospital: The role of treatment escalation plans in out-of-hours decision-making.

The journal of the Royal College of Physicians of Edinburgh·2024
Same author

Using AI to Identify Unremarkable Chest Radiographs for Automatic Reporting.

Radiology·2024
Same author

DCE-CT parameters as new functional imaging biomarkers at baseline and during immune checkpoint inhibitor therapy in patients with lung cancer - a feasibility study.

Cancer imaging : the official publication of the International Cancer Imaging Society·2024
Same journal

Mediastinal amyloidosis mimicking advanced lung cancer.

Thorax·2026
Same journal

Comparative performance of endobronchial ultrasound-guided sampling techniques in patients with mediastinal lesions: a network meta-analysis.

Thorax·2026
Same journal

Vitamin A and D impact on lung function: differential or common effects across the lifespan?

Thorax·2026
Same journal

The impact of vitamins A and D on lung function and regulatory epigenetics in adult and childhood asthma.

Thorax·2026
Same journal

Radiological factors associated with the recurrence of <i>Mycobacterium avium complex</i> pulmonary disease: a multicentre retrospective cohort study.

Thorax·2026
Same journal

Daughter vesicles in primary diaphragmatic hydatid cyst.

Thorax·2026
See all related articles

Reduced lung function is linked to higher systemic inflammation in young adults. This connection between lower lung function and increased inflammation appears early, potentially influencing cardiovascular disease risk.

Area of Science:

  • Pulmonary Medicine
  • Cardiovascular Health
  • Inflammation Research

Background:

  • Impaired lung function is a known risk factor for cardiovascular disease in older adults, linked to systemic inflammation.
  • The emergence and mediators of this association in younger populations remain unclear.
  • This study investigates the link between lung function and inflammation in young adults.

Purpose of the Study:

  • To explore the association between lung function (FEV(1)) and C-reactive protein (CRP) in young adults.
  • To determine if this association is present before the development of chronic lung disease or atherosclerosis.
  • To investigate potential mediating factors such as smoking, asthma, and obesity.

Main Methods:

  • Utilized a population-based birth cohort of approximately 1000 New Zealanders.

Related Experiment Videos

  • Assessed spirometric lung function and blood CRP levels at ages 26 and 32 years.
  • Adjusted analyses for height and sex, excluding pregnant women.

    • Main Results:

    • Significant inverse associations were observed between forced expiratory volume in one second (FEV(1)) and C-reactive protein (CRP) at both ages.
    • Similar inverse associations were found for forced vital capacity.
    • These associations were consistent in both men and women and independent of smoking, asthma, and body mass index.

    Conclusions:

    • Reduced lung function is associated with systemic inflammation in young adults.
    • This link is not explained by smoking, asthma, or obesity.
    • The findings suggest that the association between lower lung function and increased inflammation precedes chronic lung disease or significant atherosclerosis, potentially mediating cardiovascular disease risk.